Description

PhD in analytical chemistry, I have 25 years of experience in research. I am an expert in Mass Spectrometry, Skin Biology, Cutaneous Absorption, Metabolism and Bioanalysis. I know universe of cosmetic, pharmaceutic and food. I am curious, my action is at the interface of different field. Pragmatic, I am always looking for the best solution for a given challenge. Passionate, I like to share my passion and my knowledges. My commitment appears through about fifty scientific papers, resulting of a collaborative work. My experience allows me to define upstream research program, experimental work or to solve wide range of issues.

Domaines d’expertise

Langues

Français
Bilingue ou natif
Anglais
Capacité professionnelle complète

Préférences en matière de lieu de travail

Accepte de travailler sur site

Paris (jusqu’à 50 km)

Freelance
Consultant
octobre 2024 - Aujourd'hui (1 an et 8 mois)
Mission:
• Support development of analytical methods to quantify chemical in biological fluids.
• Support to ADME characterization for topical products

Achievements:
• Transfer of in silico model dedicated to cutaneous absorption
• Development of an exposure model to volatile chemicals
• Mass spectrometry training for quantification of proteins.
L'Oréal, Aulnay sous Bois (Cosmetic)
Senior Research Associate
CENTRES DE RECHERCHE
avril 2003 - septembre 2024 (21 ans et 5 mois)
Mission:
• Support conception and development of new safe and performant cosmetics products (raw material and formulation) through their ADME properties
• L'Oréal representative at Cosmetic Europe : Development and advocacy of alternative methods to animal testing : local tolerance (sensitization) and systemic toxicity (LRSS and ICCS programs)

Achievements:
• Development of LC/MS and GC/MS methods for quantitative and qualitative analysis (small chemicals, vegetal extracts, peptides, proteins,…)
• Development of LC/MS methods on Q-exactive system for metabolites and degradation products identification
• Development of ADME methods dedicated to cosmetics raw materials
• Development of methods for skin absorption using different membranes (ex vivo skin, reconstructed skin, synthetic membranes,…)
• Development of methods dedicated to skin imaging (CARS, MALDI, SIMS)
• Development and validation of skin absorption QSAR models
• Deployment aux PBPK approaches for cosmetic applications
• Development and set up of in vivo protocol to measure skin absorption
• Setup a CRO network (Aliri, Eurofins, Pharmacelsus, Biogalenys, Biomeca,…)
• Support brands for claim
• Team management (4 people)
(Pfizer, Synthelabo, Innothera, Rhône-Poulenc, Aralco, Servier)
Research Scientist
CENTRES DE RECHERCHE
septembre 1997 - avril 2003 (5 ans et 7 mois)
• Development of high throughput analytical method with one sample analyzed every 25 seconds
• Development and validation of an analytical method to characterize a drug counterfeit through synthetic impurities using a first-generation LC-ToF.
• Set up of LC/MS/MS activities for ADME, metabolites identification and quantitative analysis in biological fluid.
• Development and validation of an analytical method by LC/MS/MS for quantitative analysis of plasma samples dedicated to GLP studies (pre-clinical, Phase 1 et Phase 2)
• Set up of ISO9001 quality system for GC/MS activity dedicated to flood favor characterization
• Development of GC/MS and LC/MS activities for synthetic impurities characterization in pre clinical and clinical batches